标题 | Post-oral infusion sites that support glucose-conditioned flavor preferences in rats. |
文章类型 | Journal Article |
发表年度 | 2010 |
作者 | Ackroff, K. [1], Yiin Y. - M. [2], & Sclafani A. [3] |
期刊 | Physiology & behavior |
卷 | 99 |
期 | 3 |
页码 | 402-11 |
发表日期 | 2010 Mar 3 |
关键词 | Animals [4], Conditioning, Classical [5], Duodenum [6], Food Preferences [7], Glucose [8], Ileum [9], Infusions, Intravenous [10], Intubation, Gastrointestinal [11], Jejunum [12], Male [13], Rats [14], Rats, Sprague-Dawley [15], Reinforcement (Psychology) [16], 味觉生理 [17], 嗅觉生理 [18], 食物选择 [19] |
摘要 | Rats learn to prefer a flavored solution (CS+) paired with a gastrointestinal glucose infusion over an alternate flavor (CS-) paired with a non-caloric infusion. Prior work implicates a post-gastric site of glucose action, which is the focus of this study. In Exp. 1, male rats (8-10/group) were infused in the duodenum (ID), mid-jejunum (IJ), or distal ileum (II) with 8% glucose or water as they drank saccharin-sweetened CS+ and CS- solutions, respectively, in one-bottle 30-min sessions. Two-bottle tests (no infusions) were followed by a second train-test cycle. By the second test, the ID and IJ groups preferred the CS+ (69%, 67%) to the CS- but the II group did not (48%). Satiation tests showed that ID and IJ infusions of glucose reduced intake of a palatable solution similarly, while II infusions were ineffective. In Exp. 2, rats (10/group) drank CS solutions in one-bottle, 30-min sessions and were given 2-h ID or hepatic portal vein (HP) infusions. The CS+ and CS- were paired with 10 ml infusions of 10% glucose and 0.9% saline, respectively. Following 8 training sessions, the ID group preferred the CS+ (67%) to the CS- but the HP group did not (47%) in a two-bottle test. The similar CS+ preferences displayed by ID and IJ, but not II groups implicate the jejunum as a critical site for glucose-conditioned preferences. A pre-absorptive glucose action is indicated by the CS+ preference displayed by ID but not HP rats in Exp. 2. Our data were obtained with non-nutritive CS solutions. HP glucose infusions are reported to condition preferences for a flavored food that itself has pre- and post-absorptive actions. Thus, there may be multiple sites for glucose conditioning with the upper or mid-intestines being the first site of action. |
URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813956/pdf/nihms166146.pdf [20] |
Alternate Journal | Physiol. Behav. |
Links:
[1] http://www.hisynergi.com/literature/author/258
[2] http://www.hisynergi.com/literature/author/293
[3] http://www.hisynergi.com/literature/author/259
[4] http://www.hisynergi.com/literature/keyword/1
[5] http://www.hisynergi.com/literature/keyword/255
[6] http://www.hisynergi.com/literature/keyword/371
[7] http://www.hisynergi.com/literature/keyword/8
[8] http://www.hisynergi.com/literature/keyword/121
[9] http://www.hisynergi.com/literature/keyword/372
[10] http://www.hisynergi.com/literature/keyword/373
[11] http://www.hisynergi.com/literature/keyword/353
[12] http://www.hisynergi.com/literature/keyword/374
[13] http://www.hisynergi.com/literature/keyword/155
[14] http://www.hisynergi.com/literature/keyword/345
[15] http://www.hisynergi.com/literature/keyword/346
[16] http://www.hisynergi.com/literature/keyword/348
[17] http://www.hisynergi.com/literature/keyword/356
[18] http://www.hisynergi.com/literature/keyword/298
[19] http://www.hisynergi.com/literature/keyword/262
[20] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813956/pdf/nihms166146.pdf