Diabetic rats prefer glucose-paired flavors over fructose-paired flavors.
标题 | Diabetic rats prefer glucose-paired flavors over fructose-paired flavors. |
文章类型 | Journal Article |
发表年度 | 1997 |
作者 | Ackroff, K., Sclafani A., & Axen K. V. |
期刊 | Appetite |
卷 | 28 |
期 | 1 |
页码 | 73-83 |
发表日期 | 1997 Feb |
关键词 | Animals, Diabetes Mellitus, Experimental, Female, Food Preferences, Fructose, Glucose, Insulin, Rats, Reinforcement (Psychology), Streptozocin, Taste, 味觉生理, 食物选择 |
摘要 | Prior studies indicate that glucose has a more potent postingestive reinforcing effect than fructose. The role of insulin in this effect was examined by comparing sugar-conditioned flavor preferences in normal and streptozotocin-diabetic rats. In Experiment 1, diabetic rats, like normal rats, preferred a cue flavor that had been mixed into 8% glucose solution over a flavor mixed with 8% fructose. Both taste and postingestive properties of glucose may have contributed to this preference. Experiment 2 evaluated postingestive reinforcement by pairing cue flavors with intragastric infusions of glucose and fructose. Both diabetics and normals acquired a preference for the flavor paired with intragastric 16% glucose infusions over the flavor paired with 16% fructose infusions although the preference was somewhat smaller in the diabetic rats. Taken together, the results indicate that a normal insulin secretory response to glucose is not required for glucose-conditioned flavor preference. The diabetic rats' reduced flavor preference in Experiment 2 suggests that insulin may play some role in glucose conditioning although this may be secondary to alterations in gastrointestinal motility characteristic of diabetic animals. |
Alternate Journal | Appetite |