标题 | Oral, post-oral and genetic interactions in sweet appetite. |
文章类型 | Journal Article |
发表年度 | 2006 |
作者 | Sclafani, A. [1] |
期刊 | Physiology & behavior |
卷 | 89 |
期 | 4 |
页码 | 525-30 |
发表日期 | 2006 Nov 30 |
关键词 | Animals [2], Appetite Regulation [3], Choice Behavior [4], Dose-Response Relationship, Drug [5], Mice [6], Mice, Inbred C57BL [7], Mice, Inbred Strains [8], Mouth [9], Receptors, G-Protein-Coupled [10], Reinforcement (Psychology) [11], Species Specificity [12], Sucrose [13], Sweetening Agents [14], Taste [15], 味觉生理 [16] |
摘要 | Inbred mouse strains differ in their preferences for sweeteners, due in part to variations in their T1R3 sweet taste receptor. Recent studies of sweet sensitive C57BL/6J (B6) and subsensitive 129P3/J (129) mice indicate that experiential and post-oral effects of sugar substantially modify sweetener preference. In fact, the strain difference in sucrose preference disappeared after the mice were given 23 h/day tests with sucrose at ascending concentrations (0.5-32%). Intragastric infusions of sucrose (16%) also conditioned increased preference for and absolute intake of flavored sweet solutions in B6 and 129 mice. An operant analysis of sweetener appetite revealed, unexpectedly, that sugar-experienced 129 mice respond more vigorously than B6 mice for 16% sucrose rewards. These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite. |
Alternate Journal | Physiol. Behav. |
全文 |
Links:
[1] http://www.hisynergi.com/literature/author/259
[2] http://www.hisynergi.com/literature/keyword/1
[3] http://www.hisynergi.com/literature/keyword/488
[4] http://www.hisynergi.com/literature/keyword/185
[5] http://www.hisynergi.com/literature/keyword/209
[6] http://www.hisynergi.com/literature/keyword/285
[7] http://www.hisynergi.com/literature/keyword/367
[8] http://www.hisynergi.com/literature/keyword/489
[9] http://www.hisynergi.com/literature/keyword/490
[10] http://www.hisynergi.com/literature/keyword/463
[11] http://www.hisynergi.com/literature/keyword/348
[12] http://www.hisynergi.com/literature/keyword/124
[13] http://www.hisynergi.com/literature/keyword/125
[14] http://www.hisynergi.com/literature/keyword/2
[15] http://www.hisynergi.com/literature/keyword/4
[16] http://www.hisynergi.com/literature/keyword/356
[17] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364709/