标题 | Flavor preferences conditioned by post-oral infusion of monosodium glutamate in rats. |
文章类型 | Journal Article |
发表年度 | 2011 |
作者 | Ackroff, K. [1], & Sclafani A. [2] |
期刊 | Physiology & behavior |
卷 | 104 |
期 | 3 |
页码 | 488-94 |
发表日期 | 2011 Sep 1 |
关键词 | Animals [3], Conditioning, Classical [4], Conditioning, Operant [5], Drinking [6], Food Additives [7], Food Preferences [8], Inosine Monophosphate [9], Intubation, Gastrointestinal [10], Male [11], Rats [12], Rats, Sprague-Dawley [13], Reinforcement Schedule [14], saccharin [15], Sodium Glutamate [16], Stomach [17], Sweetening Agents [18], Water Deprivation [19] |
摘要 | Monosodium glutamate (MSG), the prototypical umami source, can enhance preference for associated flavors in humans and rodents. Although MSG flavor preference has been attributed to its taste, vagally-mediated post-oral detection has also been demonstrated. Recent studies showed that water-restricted rats acquired a preference for a flavor paired with intragastric (IG) infusion of 60 mM MSG in rats. The present study extends this work by comparing MSG-based flavor conditioning in water- and food-restricted rats and testing the persistence of flavor preferences. Rats with IG catheters drank flavored solutions paired with volume-matched infusions of 60 mM MSG or water in daily 30-min sessions. Two training/test cycles were conducted, each with eight one-bottle training sessions followed by two two-bottle preference tests without infusions. Food- and water-restricted groups displayed similar preferences for the MSG-paired flavor. When non-reinforced testing was continued after the second cycle, the food-restricted group sustained its preference across three 2-day tests, but water-restricted rats lost their preference. Other food-restricted rats learned to prefer a flavor paired with intraduodenal infusion, indicating that gastric stimulation by MSG is not required. A third experiment showed that adding 2 mM of the nucleotide inosine monophosphate to the IG infusion of MSG did not significantly enhance flavor conditioning. Because MSG-based flavor preferences can be obtained with infusions that bypass the stomach, the site for detecting MSG reinforcement may be intestinal. |
Alternate Journal | Physiol. Behav. |
Links:
[1] http://www.hisynergi.com/literature/author/258
[2] http://www.hisynergi.com/literature/author/259
[3] http://www.hisynergi.com/literature/keyword/1
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[19] http://www.hisynergi.com/literature/keyword/331