Oral, post-oral and genetic interactions in sweet appetite.
Title | Oral, post-oral and genetic interactions in sweet appetite. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Sclafani, A. |
Journal | Physiology & behavior |
Volume | 89 |
Issue | 4 |
Pagination | 525-30 |
Date Published | 2006 Nov 30 |
Keywords | Animals, Appetite Regulation, Choice Behavior, Dose-Response Relationship, Drug, Mice, Mice, Inbred C57BL, Mice, Inbred Strains, Mouth, Receptors, G-Protein-Coupled, Reinforcement (Psychology), Species Specificity, Sucrose, Sweetening Agents, Taste, 味觉生理 |
Abstract | Inbred mouse strains differ in their preferences for sweeteners, due in part to variations in their T1R3 sweet taste receptor. Recent studies of sweet sensitive C57BL/6J (B6) and subsensitive 129P3/J (129) mice indicate that experiential and post-oral effects of sugar substantially modify sweetener preference. In fact, the strain difference in sucrose preference disappeared after the mice were given 23 h/day tests with sucrose at ascending concentrations (0.5-32%). Intragastric infusions of sucrose (16%) also conditioned increased preference for and absolute intake of flavored sweet solutions in B6 and 129 mice. An operant analysis of sweetener appetite revealed, unexpectedly, that sugar-experienced 129 mice respond more vigorously than B6 mice for 16% sucrose rewards. These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite. |
Alternate Journal | Physiol. Behav. |
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